ncRNA name | PTN siRNA |
ncRNA Category | siRNA |
Disease name | proliferative vitreoretinopathy (PVR) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | immunofluorescence, siRNA transfection, CCK-8 assay, transwell assay, qPCR, Western blot, immunocytochemistry |
Expression pattern | associated |
Functional description | PTN knockdown attenuated the TGF-β1-induced migration, proliferation, cytoskeletal rearrangement, and expression of EMT markers such as α-SMA and fibronectin in the ARPE-19 cells, and these effects may have been mediated through p38 MAPK signaling pathway activation. |
PubMed ID | 28083679 |
Year | 2017 |
Title | The effects of pleiotrophin in proliferative vitreoretinopathy. |
Drug-related ncRNA | NO |
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